4-Methylaminobutanoate oxidase (formaldehyde-forming)

4-methylaminobutanoate oxidase (formaldehyde-forming)
Identifiers
EC no.1.5.3.19
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

4-methylaminobutanoate oxidase (formaldehyde-forming) (EC 1.5.3.19, mabO (gene)) is an enzyme with systematic name 4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming). This enzyme catalyses the following chemical reaction

2D representation of the chemical structure of Q27117251.
4-(methylamino)butyric acid
+ H2O
 
 
O2
H2O2
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
O2
H2O2
 
 

This enzyme is a flavoprotein containing flavin adenine dinucleotide.[1] It is involved in the metabolism of nicotine in Arthrobacter nicotinovorans.[2]

References

  1. ^ Enzyme 1.5.3.19 at KEGG Pathway Database.
  2. ^ Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R (December 2004). "A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1" (PDF). European Journal of Biochemistry. 271 (23–24): 4677–84. doi:10.1111/j.1432-1033.2004.04432.x. PMID 15606755.